Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schitter, G; Scheucher, E; Steiner, AJ; Stütz, AE; Thonhofer, M; Tarling, CA; Withers, SG; Wicki, J; Fantur, K; Paschke, E; Mahuran, DJ; Rigat, BA; Tropak, M; Wrodnigg, TM.
Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors.
Beilstein J Org Chem. 2010; 6(2):21-21
Doi: 10.3762/bjoc.6.21
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- Co-Autor*innen der Med Uni Graz
- Fantur Katrin Medea-Emma
- Paschke Eduard
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- Abstract:
- N-Alkylation at the ring nitrogen of the D-galactosidase inhibitor 1-deoxygalactonojirimycin with a functionalised C ₆alkyl chain followed by modification with different aromatic substituents provided lipophilic 1-deoxygalactonojirimycin derivatives which exhibit inhibitory properties against β-glycosidases from E. coli and Agrobacterium sp. as well as green coffee bean α-galactosidase. In preliminary studies, these compounds also showed potential as chemical chaperones for GM1-gangliosidosis related β-galactosidase mutants.
- Find related publications in this database (Keywords)
- chemical chaperones
- 1-deoxy-D-galactonojirimycin
- iminosugars
- lipophilic galactosidase inhibitor
- N-modified iminosugars