Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle-Juettner, FM; Maier, A; Lindenmann, J; Matzi, V; Neubock, N.
Resection in Stage I/II Non-Small Cell Lung Cancer
FRONT RADIAT THER ONCOL. 2010; 42: 71-77.
Doi: 10.1159/000262462
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Smolle-Juettner Freyja-Maria
- Co-Autor*innen der Med Uni Graz
- Fink-Neuböck Nicole
- Lindenmann Jörg
- Maier Alfred
- Matzi Veronika
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- Abstract:
- In spite of the developments in chemo- and radiotherapy, surgery remains the mainstay of curative treatment of early stage non-small cell lung cancer (NSCLC). In stage Ia/Ib (T1, T2, N0), NSCLC lobectomy offers the best chance for cure, yielding survival rates of between 58 and 76%. Since the extent of mediastinal lymph node dissection does not seem to play a major prognostic role in stage Ia, video-thoracoscopic lobectomy yields equally good results as the open approach. Due to the necessity for a small thoracotomy when harvesting the specimen and the time-consuming lymph-node dissection minimally invasive lobar resections have failed to become routinely used. Minor resections, though sometimes necessary from the functional point of view, have a lower curative potential. They yield the best results if applied in tumors measuring less than 2 cm. Stage II, characterized by involvement of the N1-position and/or a more central tumor growth, has a 5-year survival of 45-52% and requires treatment by lobectomy or pneumonectomy. Sleeve resection may obviate the need for pneumonectomy in central upper-lobe tumors. In interlobar N1, however, pneumonectomy is indicated from the oncological point of view, since even meticulous lymph-node dissection is unable to achieve tumor control in this situation.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Non-Small-Cell Lung - pathology
- Humans -
- Lung Neoplasms - pathology
- Lymph Nodes - pathology
- Neoplasm Staging -
- Pneumonectomy -
- Thoracic Surgery, Video-Assisted -
- Thoracotomy -