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SHR Neuro Cancer Cardio Lipid Metab Microb
Prietl, B; Pilz, S; Wolf, M; Tomaschitz, A; Obermayer-Pietsch, B; Graninger, W; Pieber, TR.
Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases?
Isr Med Assoc J. 2010; 12(3):136-139
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- Leading authors Med Uni Graz
- Pieber Thomas
- Pilz Stefan
- Prietl Barbara
- Co-authors Med Uni Graz
- Graninger Winfried
- Obermayer-Pietsch Barbara
- Tomaschitz Andreas
- Wolf Michael
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- Abstract:
- Epidemiological data show significant associations of vitamin D deficiency and autoimmune diseases. Vitamin D may prevent autoimmunity by stimulating naturally occurring regulatory T cells. To elucidate whether vitamin D supplementation increases Tregs frequency (%Tregs) within circulating CD4+ T cells. We performed an uncontrolled vitamin D supplementation trial among 50 apparently healthy subjects including supplementation of 140,000 IU at baseline and after 4 weeks (visit 1). The final follow-up visit was performed 8 weeks after the baseline examination (visit 2). Blood was drawn at each study visit to determine 25-hydroxyvitamin D levels and %Tregs. Tregs were characterized as CD4+CD25++ T cells with expression of the transcription factor forkhead box P3 and low or absent expression of CD127. Forty-six study participants (65% females, mean age +/- SD 31 +/- 8 years) completed the trial. 25(OH)D levels increased from 23.9 +/- 12.9 ng/ml at baseline to 45.9 +/- 14.0 ng/ml at visit 1 and 58.0 +/- 15.1 ng/ml at visit 2. %Tregs at baseline were 4.8 +/- 1.4. Compared to baseline levels we noticed a significant increase of %Tregs at study visit 1 (5.9 +/- 1.7, P < 0.001) and 2 (5.6 +/- 1.6, P < 0.001). Vitamin D supplementation was associated with significantly increased %Tregs in apparently healthy individuals. This immunomodulatory effect of vitamin D might underlie the associations of vitamin D deficiency and autoimmune diseases. Hence, our finding provides a rationale for further studies to investigate vitamin D effects on autoimmunological processes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- C-Reactive Protein - analysis
- CD4 Lymphocyte Count -
- CD4-Positive T-Lymphocytes - cytology
- Calcium - blood
- Dietary Supplements -
- Female -
- Follow-Up Studies -
- Forkhead Transcription Factors - analysis
- Humans -
- Immunologic Factors - pharmacology
- Interleukin-2 Receptor alpha Subunit - analysis
- Interleukin-7 Receptor alpha Subunit - analysis
- Male -
- Pilot Projects -
- T-Lymphocytes, Regulatory - classification
- T-Lymphocytes, Regulatory - drug effects
- Vitamin D - analogs & derivatives
- Vitamin D - blood
- Vitamin D - pharmacology
- Vitamins - pharmacology
- Find related publications in this database (Keywords)
- 25-hydroxyvitamin D
- vitamin D
- immunology
- autoimmunity
- regulatory T cells
- Tregs