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SHR Neuro Cancer Cardio Lipid Metab Microb

Hofmeister, V; Schrama, D; Becker, JC.
Anti-cancer therapies targeting the tumor stroma
CANCER IMMUNOL IMMUNOTHER. 2008; 57(1): 1-17. Doi: 10.1007/s00262-007-0365-5
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Leading authors Med Uni Graz: Becker Jürgen Christian
Co-authors Med Uni Graz: Schrama David
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Abstract:: For anti-tumor therapy different strategies have been employed, e.g., radiotherapy, chemotherapy, or immunotherapy. Notably, these approaches do not only address the tumor cells themselves, but also the tumor stroma cells, e.g., endothelial cells, fibroblasts, and macrophages. This is of advantage, since these cells actively contribute to the proliferative and invasive behavior of the tumor cells via secretion of growth factors, angiogenic factors, cytokines, and proteolytic enzymes. In addition, tumor stroma cells take part in immune evasion mechanisms of cancer. Thus, approaches targeting the tumor stroma attract increasing attention as anti-cancer therapy. Several molecules including growth factors (e.g., VEGF, CTGF), growth factor receptors (CD105, VEGFRs), adhesion molecules (alphavbeta3 integrin), and enzymes (CAIX, FAPalpha, MMPs, PSMA, uPA) are induced or upregulated in the tumor microenvironment which are otherwise characterized by a restricted expression pattern in differentiated tissues. Consequently, these molecules can be targeted by inhibitors as well as by active and passive immunotherapy to treat cancer. Here we discuss the results of these approaches tested in preclinical models and clinical trials.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Clinical Trials as Topic -; Extracellular Matrix -; Humans -; Neoplasms - blood supply Neoplasms - therapy; Neovascularization, Pathologic - physiopathology; Stromal Cells - physiology
Find related publications in this database (Keywords): angiogenesis; endothelial cells; extra--cellular matrix; fibroblasts; invasion; therapy