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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schrama, D; Rong, XA; Eggert, AO; Andersen, MH; Pedersen, LO; Kampgen, E; Schumacher, TN; Reisfeld, RR; Becker, JC.
Shift from systemic to site-specific memory by tumor-targeted IL-2
J IMMUNOL. 2004; 172(10): 5843-5850.
Doi: 10.4049/jimmunol.172.10.5843
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
- Schrama David
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- Abstract:
- IL-2 has been approved for treatment of patients with cancer. Moreover, it has been used as a component of vaccines against cancer. In this regard, we have recently demonstrated that dendritic cell-based peptide vaccination in mice required IL-2 to mount an effective immune response against established melanoma metastases. In this study, we confirm this observation by use of tumor-targeted IL-2. However, the development of a protective systemic memory was substantially impaired by this measure, i.e., mice, which successfully rejected s.c. tumors of B16 melanoma after vaccination with dendritic cells pulsed with tyrosinase-related protein 2-derived peptides plus a boost with targeted IL-2, failed to reject a rechallenge with experimental pulmonary metastases. Detailed analysis revealed a change in the distribution of the tumor-reactive T cell population: although targeted IL-2 expanded the local effector population, tyrosinase-related protein 2-reactive T cells were almost completely depleted from lymphatic tissues.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
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- Immunotherapy, Adoptive - methods
- Interleukin-2 - administration and dosage
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- Lung Neoplasms - immunology
- Lymph Nodes - cytology
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- Melanoma, Experimental - immunology
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