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Rappl, G; Schrama, D; Hombach, A; Meuer, EK; Schmidt, A; Becker, JC; Abken, H.
CD7(-) T cells are late memory cells generated from CD7(+) T cells
REJUV RES. 2008; 11(3): 543-556. Doi: 10.1089/rej.2007.0612
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Co-authors Med Uni Graz: Becker Jürgen Christian; Schrama David
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Abstract:: CD7(-) T cells constitute a distinct subset within the CD4(+) and CD8(+) T cell populations; their developmental and functional relationship to the majority of CD7(+) T cells, however, remained so far unresolved. We here elucidate that CD7(-) cells represent aging T cells in late memory cell development characterized by a high activation threshold, low effector capacities, and high sensitivity to activation-induced cell death (AICD). In this regard, CD7(-) T cells highly express killer cell lectin-like receptor G1 (KLRG-1), harbor telomeres of shorter lengths, a decreased telomerase expression per cell, and less amounts of T cell receptor rearrangement excision circles (TRECs) compared to CD7(+) cells. CD7(-) T cells are generated in vitro from naive CD7(+) T cells upon repetitive TCR/CD28 engagement, a process that is unidirectional and requires multiple cell divisions. Consequently, clonal expansions of CD7(-) T cells in vivo are less frequent than of CD7(+) T cells, the former can be traced back to those of CD7(+) T cells.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Antigens, CD28 - physiology; Antigens, CD45 - analysis; Antigens, CD7 - analysis; Apoptosis -; Humans -; Immunologic Memory -; Receptors, Antigen, T-Cell - physiology; T-Lymphocyte Subsets - immunology