Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Terheyden, P; Brocker, EB; Becker, JC.
Clinical evaluation of in vitro chemosensitivity testing: the example of uveal melanoma
J CANCER RES CLIN ONCOL. 2004; 130(7): 395-399.
Doi: 10.1007/s00432-004-0569-4
Web of Science
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Becker Jürgen Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Purpose. Results from in vitro chemosensitivity testing recommend treosulfan/gemcitabine chemotherapy for the treatment of stage IV uveal melanoma. Methods. Twenty patients received treosulfan 3,500 mg/m(2) followed by gemcitabine 1,000 mg/m(2) on day 1 and day 8 repeated on day 29. In cases of prior chemotherapy only 75% of these dosages were used. Results. Without any patient achieving an objective response, 25% of patients (95% confidence interval, 8.6-49.1%) had stabilisation of disease. This stabilisation was associated with a prolonged median overall survival of 17 months compared with 7 months for the patients with progressive disease. First-line treatment was not associated with better response or survival although prognostic parameters did not significantly differ from that of other patients. Conclusions. The results are disappointing and question the value of individualized chemotherapy based on in vitro assays.
- Find related publications in this database (Keywords)
- melanoma
- choroidal melanoma
- metastases
- chemosensitivity testing
- polychemotherapy