Medizinische Universität Graz - Research portal
Selected Publication:
BECKER, JC; DUMMER, R; SCHMIDT, RE; BURG, G; HARTMANN, AA.
Shedding of soluble intercellular adhesion molecule 1 (ICAM-1) from melanoma cells and the effect on cellular cytotoxicity
IMMUN INFEKT. 1992; 20(2): 62-63.
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PubMed
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- ICAM-1-mediated cell-cell adhesion is essential for various immunologic functions, including non-MHC-restricted cytotoxicity. Shedding of ICAM-1 occurred after stimulation of melanoma cells with TNF alpha and IFN gamma. Soluble forms of ICAM-1 inhibited the conjugate formation of NK clones with K562 and of LAK cells with melanoma cells. Furthermore, the non-MHC-restricted cytotoxicity mediated by NK clones or LAK cells could be abrogated by soluble ICAM-1.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Adhesion -
- Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism
- Cytotoxicity, Immunologic -
- Humans -
- Immunity, Cellular -
- Intercellular Adhesion Molecule-1 -
- Interferon-gamma - pharmacology
- Melanoma - immunology Melanoma - metabolism
- Solubility -
- Tumor Cells, Cultured -
- Tumor Necrosis Factor-alpha - pharmacology
- Find related publications in this database (Keywords)
- SOLUBLE ICAM-1
- MELANOMA
- CYTOTOXICITY