Medizinische Universität Graz - Research portal
Selected Publication:
BECKER, JC; DUMMER, R; SCHWINN, A; HARTMANN, AA; BURG, G.
Circulating intercellular adhesion molecule-1 in melanoma patients: induction by interleukin-2 therapy.
J Immunother (1991). 1992; 12(2):147-150
Doi: 10.1097/00002371-199208000-00010
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Intercellular adhesion molecule-1 (ICAM-1, CD54), a molecule bound to the cell surface membrane, mediates various cell-cell interactions in inflammation and immunosurveillance. By means of a new specific enzyme-linked immunosorbent assay (ELISA) for soluble ICAM-1, free circulating ICAM-1 was measured in serum from five healthy volunteers, 10 melanoma patients at different stages of their disease, and eight patients receiving high-dose interleukin-2 (IL-2) for metastatic melanoma. No correlation between the concentration of circulating ICAM-1 and the tumor burden could be detected. In melanoma patients receiving high-dose IL-2, we observed an increase of circulating ICAM-1 of up to 200%, compared to the concentration prior to therapy, ranging between 4 and 13 ng/ml. The increase in circulating ICAM-1 was associated with the induction of tumor necrosis factor-alpha and interferon-gamma.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Adhesion Molecules - blood
- Enzyme-Linked Immunosorbent Assay -
- Humans -
- Immunotherapy -
- Intercellular Adhesion Molecule-1 -
- Interleukin-2 - therapeutic use
- Melanoma - blood Melanoma - pathology Melanoma - therapy
- Neoplasm Staging -
- Find related publications in this database (Keywords)
- INTERCELLULAR ADHESION MOLECULE-1
- MELANOMA
- INTERLEUKIN-2