Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Voigt, H; Vetter-Kauczok, CS; Schrama, D; Hofmann, UB; Becker, JC; Houben, R.
CD147 impacts angiogenesis and metastasis formation.
Cancer Invest. 2009; 27(3):329-333
Doi: 10.1080/07357900802392675
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Becker Jürgen Christian
- Co-Autor*innen der Med Uni Graz
- Schrama David
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- Abstract:
- CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis formation and angiogenesis in this model, CD147 was stably knocked down in B16 cells. This silencing of CD147 expression resulted in a reduced capability of the tumor cells to metastasize to the draining lymph nodes. Notably, the CD147 knock down caused a decreased VEGF expression in vivo accompanied by reduced blood vessel formation. Thus, in the B16 melanoma model, CD147 promotes metastasis formation by induction of angiogenesis in an MMP independent manner.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigens, CD147 - physiology
- Antigens, CD31 - analysis
- Cell Line, Tumor -
- Melanoma, Experimental - blood supply Melanoma, Experimental - secondary
- Mice -
- Neovascularization, Pathologic - etiology
- Vascular Endothelial Growth Factor A - analysis
- Find related publications in this database (Keywords)
- CD147 (EMMPRIN, Basigin)
- Melanoma model
- Angiogenesis
- Metastasis