Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hofmeister, V; Vetter, C; Schrama, D; Brocker, EB; Becker, JC.
Tumor stroma-associated antigens for anti-cancer immunotherapy.
Cancer Immunol Immunother. 2006; 55(5):481-494
Doi: 10.1007/s00262-005-0070-1
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- Führende Autor*innen der Med Uni Graz
- Becker Jürgen Christian
- Co-Autor*innen der Med Uni Graz
- Schrama David
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- Abstract:
- Immunotherapy has been widely investigated for its potential use in cancer therapy and it becomes more and more apparent that the selection of target antigens is essential for its efficacy. Indeed, limited clinical efficacy is partly due to immune evasion mechanisms of neoplastic cells, e.g. downregulation of expression or presentation of the respective antigens. Consequently, antigens contributing to tumor cell survival seem to be more suitable therapeutic targets. However, even such antigens may be subject to immune evasion due to impaired processing and cell surface expression. Since development and progression of tumors is not only dependent on cancer cells themselves but also on the active contribution of the stromal cells, e.g. by secreting growth supporting factors, enzymes degrading the extracellular matrix or angiogenic factors, the tumor stroma may also serve as a target for immune intervention. To this end several antigens have been identified which are induced or upregulated on the tumor stroma. Tumor stroma-associated antigens are characterized by an otherwise restricted expression pattern, particularly with respect to differentiated tissues, and they have been successfully targeted by passive and active immunotherapy in preclinical models. Moreover, some of these strategies have already been translated into clinical trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigens, Neoplasm - immunology
- Endothelial Cells - immunology
- Fibroblasts - immunology
- Humans -
- Immunotherapy -
- Macrophages - immunology
- Neoplasms - immunology Neoplasms - therapy
- Stromal Cells - immunology
- Find related publications in this database (Keywords)
- endothelial cells
- fibroblast
- immune therapy
- macrophage
- stroma-associated antigens