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SHR Neuro Cancer Cardio Lipid Metab Microb

Andersen, MH; Schrama, D; Straten, PT; Becker, JC.
Cytotoxic T cells.
J Invest Dermatol. 2006; 126(1):32-41 Doi: 10.1038/sj.jid.5700001 [OPEN ACCESS]
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Leading authors Med Uni Graz: Becker Jürgen Christian
Co-authors Med Uni Graz: Schrama David
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Abstract:: The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated. The key players of adaptive cellular immune responses are T lymphocytes in general and, for the effector function, cytotoxic T lymphocytes (CTLs) in particular. T lymphocytes arise in the bone marrow and migrate to the thymus for maturation. During this process, T cells somatically rearrange gene segments, eventually leading to the expression of a unique antigen-binding molecule, the T-cell receptor (TCR). This receptor allows them to monitor all cells of the body, ready to destroy any cell posing a threat to the organism. Cytotoxicity is exerted directly through the Fas or perforin pathway and/or indirectly by the release of cytokines. Obviously, the activity of such a potent cell is tightly regulated. Indeed, a predominance of stimulatory over inhibitory signals is required for effective immune responses to pathogens, and a predominance of inhibitory over stimulatory signals is required for maintenance of self-tolerance. Still, several situations occur in which an inappropriate CTL response leads to either autoimmune disease or persistence of pathogens.
Find related publications in this database (using NLM MeSH Indexing): Autoimmune Diseases - immunology; Biological Markers - analysis; Cytotoxicity, Immunologic -; Humans -; Hypersensitivity, Delayed - immunology; Immunologic Surveillance -; Lymphocyte Activation -; Neoplasms - immunology; Receptors, Antigen, T-Cell - immunology; T-Lymphocytes, Cytotoxic - immunology