Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Becker, JC; Kirkwood, JM; Agarwala, SS; Dummer, R; Schrama, D; Hauschild, A.
Molecularly targeted therapy for melanoma: current reality and future options.
Cancer. 2006; 107(10):2317-2327
Doi: 10.1002/cncr.22273
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
- Schrama David
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- Abstract:
- Effective therapy for melanoma remains an unmet goal, with most traditional therapies representing inadequate trade-offs among the several goals of specificity, efficacy, and toxicity. Targeted molecular therapeutics are tailored to genetic abnormalities that are associated with tumor progression. Modulation of aberrant signaling pathways in cancer cells has the potential to provide more effective and potentially nontoxic therapy for a broad range of cancers, including melanoma. Among the possible targets in melanoma are the Ras-MAPK and PI3K/AKT signal transduction pathways, the proteasome, histone deacetylases, methyltransferases, and melanoma-induced angiogenesis.
- Find related publications in this database (using NLM MeSH Indexing)
- 1-Phosphatidylinositol 3-Kinase - antagonists and inhibitors
- Angiogenesis Inhibitors - therapeutic use
- Antineoplastic Agents - therapeutic use
- Apoptosis - drug effects
- Drug Resistance, Neoplasm -
- Genes, Tumor Suppressor - physiology
- Humans -
- Melanoma - drug therapy Melanoma - genetics
- Mitogen-Activated Protein Kinase Kinases - antagonists and inhibitors
- Models, Biological -
- Proteasome Endopeptidase Complex - antagonists and inhibitors
- Proto-Oncogene Proteins p21(ras) - antagonists and inhibitors
- Signal Transduction -
- Skin Neoplasms - drug therapy Skin Neoplasms - genetics
- Find related publications in this database (Keywords)
- kinase inhibitors
- proteasome inhibitors
- histone deacetylase inhibitors
- histone deacetylase inhibitors
- methyl transferase inhibitors
- angiogenesis