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SHR Neuro Cancer Cardio Lipid Metab Microb

Fensterle, J; Trefzer, U; Berger, T; Andersen, MH; Ugurel, S; Becker, JC.
HLA-B8 association with late-stage melanoma - an immunological lesson?
BMC MED. 2006; 4: Doi: 10.1186/1741-7015-4-5 [OPEN ACCESS]
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Co-authors Med Uni Graz: Becker Jürgen Christian; Ugurel-Becker Selma
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Abstract:: Background: Differences in HLA allele frequencies between the diseased and healthy populations may signify efficient immune responses, a notion that has been successfully tested for infectious diseases or for association with genetic elements involved in a distinct type of immunity. This retrospective study is intended to detect differences in MHC class I carrier frequencies of advanced melanoma patients compared to healthy bone marrow donors. Methods: The HLA-A and -B carrier frequencies of 748 stage IV melanoma patients retrieved from serotyping at 6 different centers in Germany were compared using a chi-square test to 13,386 fully HLA typed bone marrow donors registered in the German national bone marrow donor registry. Results: The comparison of HLA carrier frequencies in advanced cancer patients with healthy bone marrow donors revealed a significant decrease in HLA-B8 carrier frequencies, which was also apparent in patients with advanced disease compared to patients with loco-regional disease. Conclusion: The data suggest that protective immune responses restricted to distinct MHC class I molecules may be operational in a subset of melanoma patients, which is the prerequisite for a large scale screen for the corresponding epitopes. Alternatively, the known association of the ancestral haplotype HLA-A1, -B8 and -DR3 with genetic elements such as distinct TNF-alpha alleles might have a protective effect on disease progression. In any case, identification of the cause of protection within this patient subset might lead to a significant improvement in the efficacy of current immunotherapeutic approaches.
Find related publications in this database (using NLM MeSH Indexing): Gene Frequency -; Genes, MHC Class I -; HLA-A Antigens -; HLA-B Antigens -; HLA-B8 Antigen - genetics HLA-B8 Antigen - immunology; Histocompatibility Testing -; Humans -; Immunotherapy -; Melanoma - genetics Melanoma - immunology Melanoma - pathology; Neoplasm Staging -; Phenotype -; Retrospective Studies -; Skin Neoplasms - genetics Skin Neoplasms - immunology Skin Neoplasms - pathology