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SHR Neuro Cancer Cardio Lipid Metab Microb
Zhou, H; Luo, YP; Lo, JF; Kaplan, CD; Mizutani, M; Mizutani, N; Lee, JD; Primus, FJ; Becker, JC; Xiang, R; Reisfeld, RA.
DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor.
Proc Natl Acad Sci U S A. 2005; 102(31):10846-10851
Doi: 10.1073/pnas.0502208102
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- Co-authors Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- The interaction of NKG2D, a stimulatory receptor expressed on natural killer (NK) cells and activated CD8(+) T cells, and its ligands mediates stimulatory and costimulatory signals to these cells. Here, we demonstrate that DNA-based vaccines, encoding syngeneic or allogeneic NKG2D ligands together with tumor antigens such as survivin or carcinoembryonic antigen, markedly activate both innate and adaptive antitumor immunity. Such vaccines result in highly effective, NK- and CD8(+) T cell-mediated protection against either breast or colon carcinoma cells in prophylactic and therapeutic settings. Notably, this protection was irrespective of the NKG2D ligand expression level of the tumor cells. Hence, this strategy has the potential to lead to widely applicable and possibly clinically useful DNA-based cancer vaccines.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptation, Physiological -
- Animals -
- CD8-Positive T-Lymphocytes - immunology
- Cancer Vaccines - genetics Cancer Vaccines - pharmacology
- Carcinoembryonic Antigen - genetics Carcinoembryonic Antigen - immunology
- Cell Line, Tumor -
- Female -
- HLA-A2 Antigen - genetics HLA-A2 Antigen - metabolism
- Humans -
- Immunity, Innate -
- Killer Cells, Natural - immunology
- Ligands -
- Mice -
- Mice, Inbred BALB C -
- Mice, Inbred C57BL -
- Mice, Transgenic -
- Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - immunology Microtubule-Associated Proteins - metabolism
- Minor Histocompatibility Antigens - genetics Minor Histocompatibility Antigens - immunology Minor Histocompatibility Antigens - metabolism
- NK Cell Lectin-Like Receptor Subfamily K -
- Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy
- Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Immunologic - metabolism
- Receptors, Natural Killer Cell -
- T-Lymphocytes, Cytotoxic - immunology
- Vaccines, DNA - genetics Vaccines, DNA - pharmacology
- Find related publications in this database (Keywords)
- NK cells
- NKG2D ligands
- T cells
- survivin
- Peyer's patches