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Vetter, CS; Muller-Blech, K; Schrama, D; Brocker, EB; Becker, JC.
Cytoplasmic and nuclear expression of survivin in melanocytic skin lesions.
Arch Dermatol Res. 2005; 297(1):26-30 Doi: 10.1007/s00403-005-0572-x
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Leading authors Med Uni Graz: Becker Jürgen Christian
Co-authors Med Uni Graz: Schrama David
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Abstract:: Survivin, a member of the inhibitors of apoptosis protein family, regulates both cellular proliferation and apoptotic cell death. While the human survivin gene is highly expressed in the developing fetus, in adults its expression is restricted to highly proliferating normal tissues and neoplastic tumors tissues. In the present study, we compared the expression of survivin in melanoma and benign melanocytic lesions such as junctional, compound, dermal, congenital, blue and spitz nevi. This analysis reveals a heterogeneous expression of survivin with respect to both the intensity, frequency and cellular localization. In junctional, compound and blue nevi, survivin was present in nuclear localization, whereas in spitz nevi survivin was detectable in the cytoplasm. In dermal and congenital nevi, survivin was present in both localizations with predominance of the nuclear compartment. Interestingly, this distribution was similar to that observed in primary melanoma; whereas in metastatic melanoma the predominance of the nuclear localization of survivin was lost. Our data demonstrate that although survivin is expressed in a large number of benign nevi, the balance between its cytoplasmic and nuclear expression was immensely heterogeneous between lesions with suspected different developmental origins.
Find related publications in this database (using NLM MeSH Indexing): Cell Nucleus - chemistry; Cytoplasm - chemistry; Humans -; Immunohistochemistry -; Melanoma - chemistry; Microtubule-Associated Proteins - analysis; Neoplasm Proteins - analysis; Nevus - chemistry; Skin Neoplasms - chemistry
Find related publications in this database (Keywords): survivin; melanoma; nevi