Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Straten, PT; Becker, JC.
Adoptive cell transfer in the treatment of metastatic melanoma.
J Invest Dermatol. 2009; 129(12):2743-2745
Doi: 10.1038/jid.2009.204
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- Führende Autor*innen der Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Adoptive cell therapy (ACT) for metastatic cancer is the focus of considerable research effort. Rosenberg's laboratory demonstrated a 50% response rate in stage IV melanoma patients treated with in vitro expanded tumor-infiltrating lymphocytes (TILs) and high-dose IL-2 administered after nonmyeloablative conditioning (Dudley et al., 2002a). Because early attempts to use expanded TILs in melanoma therapy failed to demonstrate better efficacy than high-dose IL-2 (Rosenberg et al., 1994), the efficacy of TILs and nonmyeloablative conditioning in combination implies that patient conditioning is crucial to clinical success. The 2002 data represent a milestone in cellular cancer therapy and a turning point for ACT in cancer treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adoptive Transfer -
- Humans -
- Melanoma - immunology Melanoma - secondary Melanoma - therapy
- Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - therapy