Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Terheyden, P; Kortum, AK; Schulze, HJ; Durani, B; Remling, R; Mauch, C; Junghans, V; Schadendorf, D; Beiteke, U; Junger, M; Becker, JC; Brocker, EB.
Chemoimmunotherapy for cutaneous melanoma with dacarbazine and epifocal contact sensitizers: results of a nationwide survey of the German Dermatologic Co-operative Oncology Group.
J Cancer Res Clin Oncol. 2007; 133(7):437-444
Doi: 10.1007/s00432-006-0182-9
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- Co-Autor*innen der Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- PURPOSE: To scrutinize published data from small mono-centric studies and case reports which implicated high response rates and promising survival times for a combination therapy consisting of epifocal dinitrochlorobenzene (DNCB) and dacarbazine (DTIC) for metastasized melanoma. This therapy merges the effects of an allergic contact dermatitis elicited at the site of a cutaneous metastasis, and systemic chemotherapy. METHODS: We performed a retrospective survey with nine German centers and evaluated 72 patients treated from 1993 to 2005. RESULTS: The objective response rate in stage III melanoma (n = 39) was 62%. In contrast, only 9% objective responses were observed in 33 stage IV patients. Interestingly, more than half of patients with objective remissions remained progression-free for more than 1 year irrespective of the stage of disease. CONCLUSIONS: Epifocal DNCB combined with DTIC is effective in patients with regionally metastasized melanoma not amenable to surgery or isolated limb perfusion, whereas in stage IV disease in spite of few durable remissions the addition of DNCB does not improve the therapeutic efficacy of DTIC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Dacarbazine - administration and dosage
- Dinitrochlorobenzene - administration and dosage
- Disease-Free Survival -
- Female -
- Germany -
- Humans -
- Irritants - administration and dosage
- Male -
- Melanoma -
- Middle Aged -
- Neoplasm Metastasis -
- Neoplasm Staging -
- Prognosis -
- Retrospective Studies -
- Skin Neoplasms - drug therapy
- Survival Analysis -
- Find related publications in this database (Keywords)
- melanoma
- metastasis
- tumor immunity
- contact dermatitis
- dinitrochlorobenzene