Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Terheyden, P; Hofmann, MA; Weininger, M; Brocker, EB; Becker, JC.
Anti-vascular endothelial growth factor antibody bevacizumab in conjunction with chemotherapy in metastasising melanoma.
J Cancer Res Clin Oncol. 2007; 133(11):897-901
Doi: 10.1007/s00432-007-0251-8
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- Co-Autor*innen der Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- PURPOSE: The combination of the antiangiogenic antibody bevacizumab with standard chemotherapy has improved the prognosis in patients with metastastic colorectal cancer and other advanced cancers. The role of combined anti-VEGF and chemotherapy in metastastic melanoma is just starting to be elucidated. METHODS: We tested this notion in three patients with advanced and therapy-refractory melanoma. RESULTS: Interestingly, two patients achieved objective regressions after three courses of therapy; the third patient, albeit progressing demonstrated a pronounced liquid necrosis in bulky lymphnode metastasis. CONCLUSION: Further studies are warranted to scrutinize these impressive therapeutic effects on the combination of bevacizumab and chemotherapy in melanoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Angiogenesis Inhibitors - therapeutic use
- Antibodies, Monoclonal - therapeutic use
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Female -
- Humans -
- Lung Neoplasms - drug therapy Lung Neoplasms - secondary
- Male -
- Melanoma - drug therapy Melanoma - secondary
- Middle Aged -
- Skin Neoplasms - drug therapy Skin Neoplasms - pathology
- Vascular Endothelial Growth Factor A - antagonists and inhibitors Vascular Endothelial Growth Factor A - immunology
- Find related publications in this database (Keywords)
- melanoma
- metastases
- therapy
- angiogenesis
- chemotherapy