Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hofmann, UB; Houben, R; Brocker, EB; Becker, JC.
Role of matrix metalloproteinases in melanoma cell invasion.
Biochimie. 2005; 87(3-4):307-314
Doi: 10.1016/j.biochi.2005.01.013
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Cutaneous melanomas are notorious for their tendency to metastasize. Essential steps in this process are the degradation of basement membranes and remodeling of the extracellular matrix (ECM) by proteolytic enzymes such as matrix metalloproteinases (MMPs), which are regulated by their tissue inhibitors (TIMPs). An MMP expression is not restricted to tumor cells but is also found in stromal cells, indicating that stroma-derived proteases may contribute to melanoma progression. The MMPs have been shown to interact with a broad range of non-matrix proteins including adhesion molecules, growth factors and mediators of angiogenesis and apoptosis. In this review, we evaluate new insights into the interplay of MMPs and their molecular partners in melanoma progression.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Adhesion Molecules - metabolism
- Disease Progression -
- Enzyme Activation -
- Extracellular Matrix - enzymology Extracellular Matrix - metabolism
- Gene Expression Regulation, Enzymologic -
- Humans -
- Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism
- Melanoma - enzymology Melanoma - pathology
- Models, Biological -
- Neoplasm Invasiveness -
- Stromal Cells - enzymology
- Tissue Inhibitor of Metalloproteinases - metabolism
- Find related publications in this database (Keywords)
- matrix metalloproteinases
- tissue inhibitor of matrix metalloproteinases
- adhesion molecules
- tumor-stromal interaction
- microenvironment
- melanoma progression