Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hofmann, UB; Houben, R; Brocker, EB; Becker, JC.
Role of matrix metalloproteinases in melanoma cell invasion.
Biochimie. 2005; 87(3-4):307-314 Doi: 10.1016/j.biochi.2005.01.013
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Becker Jürgen Christian
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Abstract:: Cutaneous melanomas are notorious for their tendency to metastasize. Essential steps in this process are the degradation of basement membranes and remodeling of the extracellular matrix (ECM) by proteolytic enzymes such as matrix metalloproteinases (MMPs), which are regulated by their tissue inhibitors (TIMPs). An MMP expression is not restricted to tumor cells but is also found in stromal cells, indicating that stroma-derived proteases may contribute to melanoma progression. The MMPs have been shown to interact with a broad range of non-matrix proteins including adhesion molecules, growth factors and mediators of angiogenesis and apoptosis. In this review, we evaluate new insights into the interplay of MMPs and their molecular partners in melanoma progression.
Find related publications in this database (using NLM MeSH Indexing): Cell Adhesion Molecules - metabolism; Disease Progression -; Enzyme Activation -; Extracellular Matrix - enzymology Extracellular Matrix - metabolism; Gene Expression Regulation, Enzymologic -; Humans -; Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism; Melanoma - enzymology Melanoma - pathology; Models, Biological -; Neoplasm Invasiveness -; Stromal Cells - enzymology; Tissue Inhibitor of Metalloproteinases - metabolism
Find related publications in this database (Keywords): matrix metalloproteinases; tissue inhibitor of matrix metalloproteinases; adhesion molecules; tumor-stromal interaction; microenvironment; melanoma progression