Medizinische Universität Graz - Research portal
Selected Publication:
Pedersen, LO; Vetter, CS; Mingari, MC; Andersen, MH; Straten, PT; Brocker, EB; Becker, JC.
Differential expression of inhibitory or activating CD94/NKG2 subtypes on MART-1-reactive T cells in vitiligo versus melanoma: a case report.
J Invest Dermatol. 2002; 118(4):595-599
Doi: 10.1046/j.1523-1747.2002.01698.x
(- Case Report)
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- Co-authors Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Selection and activation of T cells is tightly regulated by both antigen-specific receptors and co-receptors to ensure that responses to self antigens are largely avoided. By T cell receptor clonotypic mapping and staining with tetrameric HLA-peptide complexes, we demonstrate the presence of melanocyte differentiation antigen MART-1 specific T cells in the areas of destruction of both neoplastic and normal melanocytic cells in a case of a primary melanoma and its associated hypopigmentation. These self reactive T cells expressed CD94/NKG2 major histocompatibility complex class I specific C-type lectin-like receptors. This family of receptors includes both activating and inhibitory isoforms. Thus, we performed a detailed analysis that revealed the exclusive presence of inhibitory NKG2-A/B receptors in the vitiligo-like leukoderma, whereas both the inhibitory receptors and the activating NKG2-C/E isoforms were present within the tumor. Our data suggest the differential expression of killer inhibitory receptors as a possible mechanism to regulate T cell responses to self antigens.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD - genetics
- Antigens, Neoplasm -
- Autoimmunity - immunology
- Clone Cells -
- Gene Expression Regulation, Neoplastic - immunology
- Humans -
- Immune Tolerance - immunology
- Immunohistochemistry -
- Lectins, C-Type -
- Melanoma - immunology
- Membrane Glycoproteins - genetics
- NK Cell Lectin-Like Receptor Subfamily C -
- NK Cell Lectin-Like Receptor Subfamily D -
- Neoplasm Proteins - analysis
- Receptors, Antigen, T-Cell, alpha-beta - analysis
- Receptors, Immunologic - genetics
- Receptors, Natural Killer Cell -
- Skin Neoplasms - immunology
- T-Lymphocytes - chemistry T-Lymphocytes - cytology T-Lymphocytes - immunology
- Vitiligo - immunology
- Find related publications in this database (Keywords)
- autoimmunity
- cellular
- hypopigmentation
- immunity
- self tolerance