Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hofmann, UB; Becker, JC; Brocker, EB.
Role of matrix-degrading enzymes in melanoma progression
Hautarzt. 2002; 53(9):587-595
Doi: 10.1007/s00105-001-0301-0
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Cutaneous melanoma is an invasive and early metastazising tumor. Melanoma cells detach from the primary tumor, penetrate the basement membrane, invade lymphatics and blood vessels, and form metastases. These processes all depend on coordinated expression and/or activation of proteolytic enzymes. In addition to aspartyl- and cysteineproteinases, serine proteinases including the plasminogen activator system (uPA, uPAR, tPA, PAI-1 and PAI-2) and matrix metalloproteinases (MMPs) with their tissue inhibitors (TIMPs) play an essential role in these processes. In addition, melanoma cells require specific adhesion molecules such as integrins and CD44 for interaction with other cells and components of the extracellular matrix (ECM); these are also involved in binding activated MMPs on the cell surface. In this review we discuss these functional aspects of melanoma progression.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Disease Progression -
- Endopeptidases - physiology
- Extracellular Matrix - enzymology Extracellular Matrix - pathology
- Humans -
- Matrix Metalloproteinases - physiology
- Melanoma - enzymology Melanoma - pathology
- Neoplasm Invasiveness -
- Skin Neoplasms - enzymology Skin Neoplasms - pathology
- Find related publications in this database (Keywords)
- adhesion molecules
- extracellular matrix
- matrix metalloproteinases
- melanoma
- proteases
- tumor progression