Medizinische Universität Graz - Research portal
Selected Publication:
Schrama, D; Fuchs, E; Brocker, EB; Straten, PT; Becker, JC.
Identical T-cell receptor transcripts in multiple melanoma metastases.
Cancer Res. 2002; 62(20):5664-5667
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
- Schrama David
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- Abstract:
- Immune therapy for melanoma largely relies on preexisting T-cell responses. However, recent reports demonstrated the localized nature of such responses. Thus, we characterized the effect of immune therapy on the distribution of clonotypic T cells. To this end, we analyzed the T-cell receptor repertoire of multiple metastases of differentially treated melanoma patients revealing oligoclonal T-cell responses and the occurrence of identical T-cell clones in several metastases. However, these findings were not limited to immune therapy but were also observed after chemotherapy, suggesting its similar impact on the distribution of T cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Clone Cells -
- Electrophoresis - methods
- Female -
- Humans -
- Lymphocytes, Tumor-Infiltrating - immunology
- Male -
- Melanoma - genetics Melanoma - immunology Melanoma - secondary
- RNA, Messenger - genetics
- Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology
- Reverse Transcriptase Polymerase Chain Reaction -
- T-Lymphocytes - immunology