Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schrama, D; Straten, PT; Fischer, WH; McLellan, AD; Brocker, EB; Reisfeld, RA; Becker, JC.
Targeting of lymphotoxin-alpha to the tumor elicits an efficient immune response associated with induction of peripheral lymphoid-like tissue
IMMUNITY. 2001; 14(2): 111-121.
Doi: 10.1016/S1074-7613(01)00094-2
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- Führende Autor*innen der Med Uni Graz
- Becker Jürgen Christian
- Schrama David
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- Abstract:
- A recombinant antibody-lymphotoxin-alpha fusion protein induced an adaptive immune response protecting mice from melanoma. Importantly, this fusion protein elicited the formation of a lymphoid-like tissue in the tumor microenvironment containing L-selectin+ T cells and MHC class II+ antigen-presenting cells, as well as B and T cell aggregates. Furthermore, PNAd+/TCA4+ high endothelial venules were observed within the tumor, suggesting entry channels for naive T cell infiltrates. Over the course of therapy, a marked clonal expansion of certain TCR specificities occurred among tumor-infiltrating lymphocytes that displayed reactivity against melanoma cells and the TRP-2(180-188) peptide. Consequently, naive T cells may have been recruited to as well as primed and expanded in the lymphoid-like tissue induced by the lymphotoxin-alpha fusion protein at the tumor site.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies, Monoclonal - therapeutic use
- Endothelium, Lymphatic - immunology Endothelium, Lymphatic - pathology
- Humans -
- Immunotoxins - therapeutic use
- Lung Neoplasms - immunology Lung Neoplasms - secondary Lung Neoplasms - therapy
- Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology
- Lymphoid Tissue - immunology Lymphoid Tissue - pathology
- Lymphotoxin-alpha - therapeutic use
- Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy
- Mice -
- Mice, Inbred C57BL -
- Microscopy, Electron -
- Neoplasm Transplantation -
- Neoplasms, Connective Tissue - immunology Neoplasms, Connective Tissue - pathology Neoplasms, Connective Tissue - therapy
- Recombinant Fusion Proteins - therapeutic use
- T-Lymphocytes - immunology T-Lymphocytes - pathology
- Transplantation, Isogeneic -