Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Tomaschitz, A; Drechsler, C; Dekker, JM; März, W.
Vitamin D deficiency and myocardial diseases.
Mol Nutr Food Res. 2010; 54(8): 1103-1113.
Doi: 10.1002/mnfr.200900474
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- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Tomaschitz Andreas
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- Abstract:
- Vitamin D deficiency is common among patients with myocardial diseases because sun-induced vitamin D production in the skin and dietary intake of vitamin D is often insufficient. Knockout mice for the vitamin D receptor develop myocardial hypertrophy and dysfunction. It has also been shown that children with rickets who suffered from severe heart failure could be successfully treated with supplementation of vitamin D plus calcium. In adults, almost all patients with heart failure exhibit reduced 25-hydroxyvitamin D levels, which are used to classify the vitamin D status. In prospective studies, vitamin D deficiency was an independent risk factor for mortality, deaths due to heart failure and sudden cardiac death. Several vitamin D effects on the electrophysiology, contractility, and structure of the heart suggest that vitamin D deficiency might be a causal factor for myocardial diseases. Data from interventional trials, however, are rare and urgently needed to elucidate whether vitamin D supplementation is useful for the treatment of myocardial diseases. In our opinion, the current knowledge of the beneficial effects of vitamin D on myocardial and overall health strongly argue for vitamin D supplementation in all vitamin D-deficient patients with or at high risk for myocardial diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- 25-Hydroxyvitamin D 2 - blood
- Adult -
- Animals -
- Calcifediol - blood
- Cardiomyopathies - complications
- Child -
- Dietary Supplements -
- Heart - drug effects
- Humans -
- Infant -
- Myocardium - metabolism
- Risk Factors -
- Vitamin D - metabolism
- Vitamin D Deficiency - blood
- Find related publications in this database (Keywords)
- Cardiac
- Heart failure
- Myocardial diseases
- Sudden cardiac death
- Vitamin D