Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoffmann, KM; Deutschmann, A; Weitzer, C; Joainig, M; Zechner, E; Högenauer, C; Hauer, AC.
Antibiotic-Associated Hemorrhagic Colitis Caused by Cytotoxin-Producing Klebsiella oxytoca.
Pediatrics. 2010; 125(4):e960-e963
Doi: 10.1542/peds.2009-1751
(- Case Report)
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hoffmann Karl Martin
- Co-Autor*innen der Med Uni Graz
- Deutschmann Andrea
- Hauer Almuthe
- Hoegenauer Christoph
- Joainig Martina
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Klebsiella oxytoca was recently described as the causative organism for antibiotic-associated hemorrhagic colitis (AAHC). It is currently not known if this novel gastrointestinal infection exists in children. AAHC is usually preceded by antibiotic treatment with penicillins, which are frequently prescribed for pediatric patients. In contrast to colitis caused by Clostridium difficile, colitis caused by K oxytoca is usually segmental and located predominantly in the right colon. Patients with AAHC typically present with abdominal pain and almost always bloody diarrhea. We present here the case of an adolescent patient who developed acute abdominal pain and bloody diarrhea after antibiotic treatment for acute urinary infection with amoxicillin-clavulanate. Right-sided colitis was verified by abdominal sonography. Stool culture tested negative for common gastrointestinal pathogens but yielded K oxytoca. Toxin production of the isolated strain was verified in a cell-culture assay. Cessation of the causative antibiotic treatment led to rapid improvement and cessation of bloody diarrhea within 3 days. We report here the first (to our knowledge) pediatric case of K oxytoca infection causing AAHC. Establishing the diagnosis of AAHC by culturing K oxytoca and demonstrating right-sided colitis with noninvasive imaging studies might prevent unnecessary invasive procedures in children with bloody diarrhea.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antibiotics, Antineoplastic - adverse effects
- Cytotoxins - adverse effects Cytotoxins - biosynthesis
- Enterocolitis, Pseudomembranous - chemically induced Enterocolitis, Pseudomembranous - microbiology Enterocolitis, Pseudomembranous - ultrasonography
- Humans -
- Klebsiella Infections - chemically induced Klebsiella Infections - microbiology Klebsiella Infections - ultrasonography
- Klebsiella oxytoca - isolation and purification
- Male -
- Find related publications in this database (Keywords)
- Klebsiella oxytoca
- antibiotic-associated hemorrhagic colitis
- children
- bloody diarrhea
- ultrasound