Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sharma, S; Mann, D; Singh, TP; Ghosh, B.
Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.
J Hum Genet. 2005; 50(12):611-617
Doi: 10.1007/s10038-005-0302-4
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- Co-Autor*innen der Med Uni Graz
- Singh Tej Pratap
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- Abstract:
- Histamine plays a major role in allergic disorders, including asthma. A major pathway of histamine biotransformation in the lungs is mediated by histamine N-methyltransferase (HNMT). We investigated the association of a functional SNP C314T; a SNP A929G, a (CA)n repeat in intron 5, and a novel (CA)n repeat (BV677277), 7.5 kb downstream of the HNMT gene with asthma and its associated traits such as total serum IgE levels in a case-control as well as in a family-based study design. In contrast to a previous study, no association was observed for the polymorphisms investigated with asthma (P>0.05). When haplotypes were constructed for these loci and compared, no significant difference was observed in the distribution between cases and controls. In the family-based design, no biased transmission was observed for any of the polymorphisms and haplotypes with asthma using the additive model of inheritance in family-based association test (FBAT). Thus, consistent with the case-control findings, the polymorphisms and haplotypes in the HNMT gene are not associated with asthma in the Indian population.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Asthma - epidemiology Asthma - genetics Asthma - immunology
- Case-Control Studies -
- Child -
- Child, Preschool -
- Female -
- Gene Frequency -
- Genetic Predisposition to Disease -
- Haplotypes -
- Histamine N-Methyltransferase - genetics
- Humans -
- Immunoglobulin E - blood
- India - epidemiology
- Male -
- Polymorphism, Genetic -
- Find related publications in this database (Keywords)
- asthma
- histamine N-methyltransferase (HNMT)
- genetic association studies
- haplotypes
- Indian population
- SNPs
- serum IgE