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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Balassy, C; Kasprian, G; Brugger, PC; Weber, M; Csapo, B; Herold, C; Prayer, D.
Assessment of lung development in isolated congenital diaphragmatic hernia using signal intensity ratios on fetal MR imaging.
Eur Radiol. 2010; 20(4):829-837
Doi: 10.1007/s00330-009-1633-x
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Csapo Bence Daniel
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- Abstract:
- To investigate developmental changes in the apparently unaffected contralateral lung by using signal intensity ratios (SIR) and lung volumes (LV), and to search for correlation with clinical outcome. Twenty-five fetuses (22-37 weeks' gestation) were examined. Lung/liver signal intensity ratios (LLSIR) were assessed on T1-weighted and T2-weighted sequences for both lungs, then together with LV compared with age-matched controls of 91 fetuses by using the U test. Differences in LLSIRs and lung volumes were correlated with neonatal outcomes. LLSIRs in fetuses with congenital diaphragmatic hernia (CDH) were significantly higher in both lungs on T1-weighted images and significantly lower on T2-weighted images, compared with normals (p < 0.05), increasing on T2-weighted imaging and decreasing on T1-weighted imaging during gestation. Total LV were significantly smaller in the CDH group than in controls (p < 0.05). No significant differences in LLSIR of the two lungs were found. Outcomes correlated significantly with total LV, but not with LLSIR. Changes in LLSIR seem to reflect developmental impairment in CDH; however, they provide no additional information in predicting outcome. LV remains the best indicator on fetal MR imaging of neonatal survival in isolated, left-sided CDH.
- Find related publications in this database (using NLM MeSH Indexing)
- Algorithms -
- Female -
- Hernia, Diaphragmatic - congenital Hernia, Diaphragmatic - pathology
- Humans -
- Image Enhancement - methods
- Image Interpretation, Computer-Assisted - methods
- Lung - embryology Lung - pathology
- Magnetic Resonance Imaging - methods
- Male -
- Prenatal Diagnosis - methods
- Reproducibility of Results -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- Fetal MR imaging
- Signal intensities
- Congenital diaphragmatic hernia
- Fetal lung
- Structural changes