Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Balassy, C; Kasprian, G; Brugger, PC; Csapo, B; Weber, M; Hörmann, M; Bankier, A; Bammer, R; Herold, CJ; Prayer, D.
Diffusion-weighted MR imaging of the normal fetal lung.
Eur Radiol. 2008; 18(4): 700-706.
Doi: 10.1007/s00330-007-0784-x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Csapo Bence Daniel
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- Abstract:
- To quantify apparent diffusion coefficient (ADC) changes in fetuses with normal lungs and to determine whether ADC can be used in the assessment of fetal lung development. In 53 pregnancies (20-37th weeks of gestation), we measured ADC on diffusion-weighted imaging (DWI) in the apical, middle, and basal thirds of the right lung. ADCs were correlated with gestational age. Differences between the ADCs were assessed. Fetal lung volumes were measured on T2-weighted sequences and correlated with ADCs and with age. ADCs were 2.13 +/- 0.44 microm(2)/ms (mean +/- SD) in the apex, 1.99 +/- 0.42 microm(2)/ms (mean +/- SD) in the middle third, and 1.91 +/- 0.41 microm(2)/ms (mean +/- SD) in the lung base. Neither the individual ADC values nor average ADC values showed a significant correlation with gestational age or with lung volumes. Average ADCs decreased significantly from the lung apex toward the base. Individual ADCs showed little absolute change and heterogeneity. Lung volumes increased significantly during gestation. We have not been able to identify a pattern of changes in the ADC values that correlate with lung maturation. Furthermore, the individual, gravity-related ADC changes are subject to substantial variability and show nonuniform behavior. ADC can therefore not be used as an indicator of lung maturity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cross-Sectional Studies -
- Diffusion Magnetic Resonance Imaging - methods
- Female -
- Gestational Age -
- Humans -
- Lung - embryology
- Pregnancy -
- Statistics, Nonparametric -
- Find related publications in this database (Keywords)
- retal lung
- diffusion-weighted MR imaging
- apparent diffusion coefficient
- lung development