Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Balássy, C; Bernert, G; Wöber-Bingöl, C; Csapó, B; Kornek, B; Széles, J; Fleischmann, D; Prayer, D.
Long-term MRI observations of childhood-onset relapsing-remitting multiple sclerosis.
Neuropediatrics. 2001; 32(1):28-37
Doi: 10.1055/s-2001-12219
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Csapo Bence Daniel
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- Abstract:
- PURPOSE: Long-term MRI follow-up of childhood-onset relapsing-remitting multiple sclerosis (RRMS) was carried out in 4 cases. MRI findings were correlated with clinical course and characteristic differences from adult-onset RRMS were elaborated. METHODS: Two girls and one boy with true childhood-onset, and one girl with juvenile-onset RRMS underwent 5-16 MRI examinations within 6-8 years. The total number of lesions, the numbers of new, active, disappearing and reappearing lesions, infratentorial and U-fibre lesions, "giant" plaques and "black holes" were counted. Callosal atrophy and general brain atrophy were assessed. The findings were related to the physical status according to the Expanded Disability Status Scale (EDSS). RESULTS AND CONCLUSIONS: Results showed that the primary differences in childhood-onset RRMS compared to adult-onset RRMS lie in the lack of, or slower development of irreversible changes ("black hole" formation, brain atrophy). Despite callosal atrophy and intensive U-fibre region involvement, school performance was unchanged. Regarding the frequency of "giant" lesions, an even more pronounced white matter involvement was found in our children compared to adults. All children exhibited a rather "benign" disease course. A more intensive remyelination, less severe neuronal loss, and higher functional brain plasticity at younger ages may account for these differences.
- Find related publications in this database (using NLM MeSH Indexing)
- Atrophy -
- Brain - pathology
- Child -
- Corpus Callosum - pathology
- Female -
- Follow-Up Studies -
- Humans -
- Image Processing, Computer-Assisted -
- Magnetic Resonance Imaging -
- Male -
- Multiple Sclerosis, Relapsing-Remitting - diagnosis
- Neurologic Examination -
- Find related publications in this database (Keywords)
- multiple sclerosis
- MRI
- childhood-onset
- long-term follow-up