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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Massone, C; Nunzi, E; Ribeiro-Rodrigues, R; Talhari, C; Talhari, S; Schettini, AP; Parente, JN; Brunasso, AM; Puntoni, M; Clapasson, A; Noto, S; Cerroni, L.
T regulatory cells and plasmocytoid dentritic cells in hansen disease: a new insight into pathogenesis?
Am J Dermatopathol. 2010; 32(3):251-256
Doi: 10.1097/DAD.0b013e3181b7fc56
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- Leading authors Med Uni Graz
- Massone Cesare
- Co-authors Med Uni Graz
- Brunasso Vernetti Alexandra Maria
- Cerroni Lorenzo
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- Abstract:
- Leprosy is characterized by spectrum of histologically different granulomatous skin lesions that reflects the patient's immune response to Mycobacterium leprae. Presence, frequency, and distribution of both CD4+ CD25+ FoxP3+ T regulatory cells (T-regs) and CD123+ plasmacytoid dendritic cells in leprosy have never been investigated. We performed a retrospective immunohistochemical study on 20 cases of leprosy [tuberculoid tuberculoid (TT): 1 patient; borderline tuberculoid (BT): 3 patients; borderline lepromatous (BL): 5 patients; lepromatous lepromatous (LL): 5 patients; borderline borderline in reversal reaction (BB-RR): 1 patient; BT-RR: 2 patients; and erythema nodosum leprosum (ENL): 3 patients]. FoxP3-positive cells were present in 95% of the cases with an average density of 2.9% of the infiltrate. Their distribution was not related to granulomatous structures or special locations. There was no statistical difference of FoxP3 expression between TT, BT, BL, and LL, whereas a statistical significant increment (P = 0.042) was observed in patients affected by reversal leprosy reactions (BT-RR and BB-RR) compared with patients affected by ENL and patients with nonreactional disease forms (BL, LL, BT, TT). CD123 expression was not observed in any of the biopsy specimens evaluated; with the exception of 2 cases of ENL, in which a focal positivity for CD123 was observed. Our results show that plasmacytoid dendritic cells are not involved in the immune response against M. leprae while T-regs are present in leprosy skin lesions. These data raise the question if T-regs have a pathogenetic role in HD as previously demonstrated in Leishmania major and Mycobacterium tuberculosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biological Markers - metabolism
- Dendritic Cells - immunology
- Female -
- Forkhead Transcription Factors - metabolism
- Humans -
- Immunoenzyme Techniques -
- Interleukin-3 Receptor alpha Subunit - metabolism
- Leprosy - immunology Leprosy - pathology
- Male -
- Middle Aged -
- Retrospective Studies -
- T-Lymphocytes, Regulatory - immunology
- Young Adult -
- Find related publications in this database (Keywords)
- leprosy
- T regulatory cells
- plasmocytoid dentritic cells
- FoxP3
- CD123