Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bock, G; Man, CD; Micheletto, F; Basu, R; Rn, PD; Laugen, J; Deacon, CF; Holst, JJ; Toffolo, G; Cobelli, C; Rizza, RA; Vella, A.
The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose.
Clin Endocrinol (Oxf). 2010; 73(2):189-196
Doi: 10.1111/j.1365-2265.2009.03764.x
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- Treiber Gerlies
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- Abstract:
- P>Objective Low glucagon-like peptide-1 (GLP-1) concentrations have been observed in impaired fasting glucose (IFG). It is uncertain whether these abnormalities contribute directly to the pathogenesis of IFG and impaired glucose tolerance. Dipeptidyl peptidase-4 (DPP-4) inhibitors raise incretin hormone concentrations enabling an examination of their effects on glucose turnover in IFG. Research design and methods We studied 22 subjects with IFG using a double-blinded, placebo-controlled, parallel-group design. At the time of enrolment, subjects ate a standardized meal labelled with [1-13C]-glucose. Infused [6-3H] glucose enabled measurement of systemic meal appearance (MRa). Infused [6,6-2H(2)] glucose enabled measurement of endogenous glucose production (EGP) and glucose disappearance (Rd). Subsequently, subjects were randomized to 100 mg of sitagliptin daily or placebo. After an 8-week treatment period, the mixed meal was repeated. Results As expected, subjects with IFG who received placebo did not experience any change in glucose concentrations. Despite raising intact GLP-1 concentrations, treatment with sitagliptin did not alter either fasting or postprandial glucose, insulin or C-peptide concentrations. Postprandial EGP (18 center dot 1 +/- 0 center dot 7 vs 17 center dot 6 +/- 0 center dot 8 mu mol/kg per min, P = 0 center dot 53), Rd (55 center dot 6 +/- 4 center dot 3 vs 58 center dot 9 +/- 3 center dot 3 mu mol/kg per min, P = 0 center dot 47) and MRa (6639 +/- 377 vs 6581 +/- 316 mu mol/kg per 6 h, P = 0 center dot 85) were unchanged. Sitagliptin was associated with decreased total GLP-1 implying decreased incretin secretion. Conclusions DPP-4 inhibition did not alter fasting or postprandial glucose turnover in people with IFG. Low incretin concentrations are unlikely to be involved in the pathogenesis of IFG.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Glucose - drug effects
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- Fasting - blood
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- Glucose Intolerance - blood
- Humans -
- Incretins - blood
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- Middle Aged -
- Placebos -
- Postprandial Period - physiology
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- Triazoles - pharmacology