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Selected Publication:
Pfragner, R; Wirnsberger, G; Niederle, B; Behmel, A; Rinner, I; Mandl, A; Wawrina, F; Luo, JS; Adamiker, D; Hoger, H; Ingolic, E; Schauenstein, K.
Establishment of a Continuous Cell-Line from a Human Carcinoid of the Small-Intestine (KRJ-I) - Characterization and Effects of 5-Azacytidine on Proliferation
INT J ONCOL. 1996; 8: 513-520.
Doi: 10.3892/ijo.8.3.513
Web of Science
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- Leading authors Med Uni Graz
- Pfragner Roswitha
- Co-authors Med Uni Graz
- Schauenstein Konrad
- Wirnsberger Gerhard
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- Abstract:
- A new continuous cell line from a human malignant carcinoid of the small intestine (KRJ-I) was established. The cells showed morphological and immunocytochemical features of the tumor of origin and expressed estrogen receptors. The cells are growing as a suspension, forming multicellular aggregates and spheroids. Electron microscopy confirmed the presence of neuroendocrine granules. Dose-dependent growth inhibition was observed after incubation with 5-azacytidine. Cytogenetic analyses of the tumor of origin, the cell line KRJ-I and a liver metastasis KRJ-II revealed clonal tetraploidy and clonal loss of the Y-chromosome and chromosome 19.
- Find related publications in this database (Keywords)
- Human Malignant Carcinoid Cell Line of the Small Intestine
- Neuroendocrine Characteristics
- Tumorigenicity
- DNA-Methylation
- 5-Azacytidine
- Clonal Tetraploidy
- Clonal Loss of Y-Chromosome
- Clonal Trisomy 7