Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Haeubl, M; Schuerz, S; Svejda, B; Reith, LM; Gruber, B; Pfragner, R; Schoefberger, W.
Asymmetrically substituted cationic indole- and fluorene porphyrins inhibit tumor proliferation in small intestinal neuroendocrine tumors and medullary thyroid carcinomas.
Eur J Med Chem. 2010; 45(2): 760-773.
Doi: 10.1016/j.ejmech.2009.11.025
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Pfragner Roswitha
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In this study we demonstrate anticancer activity of novel fully water soluble cationic porphyrins. The two cationic porphyrins 5,10,15-tris(N-methylpyridinium-4-yl)-20-[1-phenyl-4-(3-N-phenylsulfonylindolyl)]-21H,23H-porphyrin chloride (TMPy(3)PhenIndolprot(1)P-Cl(3)) and 5-{5-[2-(9,9-Dimethyl)fluorenyl]-N-methylpyridinium-3-yl}-10,15,20-tris(N-methyl-pyridinium-4-yl)-21H,23H-porphyrin chloride (TMPy(3)PyFluorenyl(1)P-Cl(4)) were prepared and their antiproliferative effects were studied in two human tumor cell lines and a normal human fibroblast cell line. Effects of the novel porphyrin compounds were evaluated in the small intestinal neuroendocrine tumor cell line KRJ-I, the medullary thyroid carcinoma cell line MTC-SK and the normal human fibroblast cell line HF-SAR by cell counting, cell proliferation assays and cell cytotoxicity analyses. TMPy(3)PhenIndolprot(1)P-Cl(3) and TMPy(3)PyFluorenyl(1)P-Cl(4) showed antiproliferative effects in the tumor cell lines MTC-SK and KRJ-I; cell viability was decreased and cytotoxic effects were quantified, while no significant alterations of the human fibroblasts were noted. With the advantage of full water solubility and antiproliferative effects in tumor cell lines, the novel porphyrin compounds TMPy(3)PhenIndolprot(1)P-Cl(3) and TMPy(3)PyFluorenyl(1)P-Cl(4) could be a new therapeutic option in anticancer treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - chemical synthesis
- Base Sequence -
- Cattle -
- Cell Line, Tumor -
- Cell Proliferation - drug effects
- DNA - genetics
- Fluorenes - chemistry
- Humans -
- Indoles - chemistry
- Neuroendocrine Tumors - drug therapy
- Porphyrins - chemical synthesis
- Solubility -
- Thyroid Neoplasms - drug therapy
- Water - chemistry
- Find related publications in this database (Keywords)
- Cationic porphyrins
- DNA intercalators
- Indole
- Fluorene
- Cytotoxicity
- Water soluble
- Neuroendocrine tumors
- KRJ-I
- MTC-SK