Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schillinger, W; Teucher, N; Christians, C; Kohlhaas, M; Sossalla, S; Van Nguyen, P; Schmidt, AG; Schunck, O; Nebendahl, K; Maier, LS; Zeitz, O; Hasenfuss, G.
High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts.
Eur J Heart Fail. 2006; 8(7): 673-680.
Doi: 10.1016/j.ejheart.2006.01.013
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- Co-Autor*innen der Med Uni Graz
- Schmidt Albrecht
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- Abstract:
- We investigated the hypothesis that increased intracellular [Na+]i in heart failure contributes to preservation of SR Ca2+ load which may become particularly evident at slow heart rates. [Na+]i in SBFI-loaded myocytes from rabbits with pacing-induced heart failure (PHF) was significantly higher at each frequency as compared to Sham-operated animals. Furthermore, PHF rabbits demonstrated reduced SR Ca2+-ATPase protein levels (-37%, p < 0.04) but unchanged Na+/Ca2+ exchanger protein levels. At 0.25 Hz, isometric force was similar in cardiac trabeculae from PHF rabbits as compared to control (PHF, 3.6+/-1.3; Sham, 4.4+/-0.6 mN/mm2). Rapid cooling contractures (RCCs) were unchanged indicating preserved SR Ca2+ load at this frequency. In Sham, isometric twitch force increased with rising frequencies to 29.0+/-2.8 mN/mm2 at 3.0 Hz (p < 0.05) as compared to 0.25 Hz. RCCs showed a parallel increase by 186+/-47% (p < 0.01). In PHF, frequency-dependent increase in force (15.8+/-4.7 mN/mm2 at 3.0 Hz) and RCCs (increase by 70+/-40%) were significantly blunted. Thus, in PHF in rabbits SR Ca2+ load is preserved at low frequencies despite decreased SR Ca2+-ATPase expression. This may result from [Na+]i-dependent changes in Na+/Ca2+ exchanger activity.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium-Transporting ATPases - metabolism
- Disease Models, Animal -
- Electric Stimulation -
- Heart Failure - metabolism
- Muscle Cells -
- Rabbits -
- Sarcoplasmic Reticulum - metabolism
- Sodium - metabolism
- Sodium-Calcium Exchanger -
- Find related publications in this database (Keywords)
- dilated cardiomyopathy
- heart failure
- force-frequency relationship
- sodium
- animal model