Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Slack, JP; Grupp, IL; Dash, R; Holder, D; Schmidt, A; Gerst, MJ; Tamura, T; Tilgmann, C; James, PF; Johnson, R; Gerdes, AM; Kranias, EG.
The enhanced contractility of the phospholamban-deficient mouse heart persists with aging.
J Mol Cell Cardiol. 2001; 33(5): 1031-1040.
Doi: 10.1006/jmcc.2001.1370
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Schmidt Albrecht
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- Abstract:
- J. P. Slack, I. L. Grupp, R. Dash, D. Holder, A. Schmidt, M. J. Gerst, T. Tamura, C. Tilgmann, P. F. James, R. Johnson, A. M. Gerdes and E. G. Kranias. The Enhanced Contractility of the Phospholamban-deficient Mouse Heart Persists with Aging. Journal of Molecular and Cellular Cardiology (2001) 33, 1031-1040. Phospholamban ablation in the mouse is associated with significant increases in cardiac contractility. To determine whether this hyperdynamic function persists through the aging process, a longitudinal examination of age-matched phospholamban-deficient and wild-type mice was employed. Kaplan-Meier survival curves indicated no significant differences between phospholamban-deficient and wild-type mice over the first year. Examination of cardiac function revealed significant increases in the rates of contraction (+dP/dt) and relaxation (-dP/dt) in phospholamban-deficient hearts compared with their wild-type counterparts at 3, 6, 12, 18 and 24 months of age. Quantitative immunoblotting indicated that the expression levels of the sarcoplasmic reticulum Ca(2+)-ATPase were not altered in wild-type hearts, while they were significantly decreased at 12 months (40%) and 18 months (20%) in phospholamban-deficient hearts. These findings on the persistence of hyperdynamic cardiac function over the long term suggest that phospholamban may constitute an important target for treatment in heart disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aging -
- Animals -
- Blotting, Western -
- Calcium-Binding Proteins - genetics Calcium-Binding Proteins - physiology
- Echocardiography -
- Female -
- Genotype -
- Heart - physiology
- Immunoblotting -
- Male -
- Mice -
- Myocardial Contraction -
- Myocardium - metabolism
- Time Factors -
- Find related publications in this database (Keywords)
- phospholamban
- aging
- sarcoplasmic reticulum
- myocardium
- contractility