Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kiriazis, H; Sato, Y; Kadambi, VJ; Schmidt, AG; Gerst, MJ; Hoit, BD; Kranias, EG.
Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis.
Cardiovasc Res. 2002; 53(2): 372-381.
Doi: 10.1016/S0008-6363(01)00487-4
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- Co-Autor*innen der Med Uni Graz
- Schmidt Albrecht
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- Abstract:
- OBJECTIVE: To determine whether the hyperdynamic phospholamban-knockout hearts are capable of withstanding a chronic aortic stenosis. METHODS: The transverse section of the aorta was banded in phospholamban-knockout and their isogenic wild-type mice, which were followed with echocardiography in parallel, along with sham-operated mice, before and at 2.5, 5 and 10 weeks after surgery. RESULTS: Cardiac decompensation was evidenced by the presence of lung congestion in some banded knockouts and wild-types, giving rise to a subset of non-failing and failing hearts within each group. The incidence of heart failure was not genotype-dependent but rather associated with higher heart rates before surgery. The development of left ventricular hypertrophy was similar between knockouts and wild-types and longitudinal assessment of end-diastolic dimension indicated progressive increases after banding, with a greater dilation in failing mice. Fractional shortening was reduced in failing knockouts and wild-types to a similar degree, with an earlier onset in the knockouts. In addition, fractional shortening was decreased in non-failing knockouts but not wild-types. Ejection times shortened after aortic banding particularly for failing hearts. Assessment of the SR Ca(2+)-ATPase protein levels indicated similar downregulation for failing knockouts and wild-types, while the phospholamban levels were not significantly altered in wild-types. CONCLUSION: The hyperdynamic phospholamban-knockout hearts are able to compensate against a sustained aortic stenosis similar to wild-types.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Aortic Coarctation - metabolism Aortic Coarctation - physiopathology Aortic Coarctation - ultrasonography
- Calcium-Binding Proteins - analysis Calcium-Binding Proteins - genetics
- Calcium-Transporting ATPases - analysis
- Calsequestrin - analysis
- Cardiomegaly - metabolism Cardiomegaly - physiopathology Cardiomegaly - ultrasonography
- Echocardiography -
- Male -
- Mice -
- Mice, Knockout -
- Sarcoplasmic Reticulum - chemistry Sarcoplasmic Reticulum - metabolism
- Time Factors -
- Find related publications in this database (Keywords)
- Ca-pump
- heart failures
- hypertrophs
- SR (function)
- ventricular function