Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Painsipp, E; Herzog, H; Holzer, P.
Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge.
J Psychopharmacol. 2010; 24(10):1551-1560
Doi: 10.1177/0269881109348171
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Singewald Evelin
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- Abstract:
- Neuropeptide Y participates in the acute behavioural responses to immune challenge, since Y2 receptor knockout (Y2⁻/⁻) mice are particularly sensitive to the short-term anxiogenic-like effect of bacterial lipopolysaccharide. The present exploratory study addressed the involvement of Y2 and Y4 receptors in the long-term behavioural responses to immune challenge. A single intraperitoneal injection of lipopolysaccharide (0.83 mg/kg) to control mice did not affect open field behaviour 3 h post-treatment but enhanced anxiety-like behaviour in Y2⁻/⁻ as well as Y4⁻/⁻ mice. Four weeks post-treatment this behavioural effect of lipopolysaccharide persisted in Y4⁻/⁻ mice but had gone in Y2⁻/⁻ mice. Depression-related behaviour in the forced swim test was enhanced 1 day post-lipopolysaccharide in control and Y2⁻/⁻ mice, but not in Y4⁻/⁻ mice. Four weeks post-treatment, the depressogenic-like effect of lipopolysaccharide had waned in control mice, persisted in Y2⁻/⁻ mice and was first observed in Y4⁻/⁻ mice. In summary, knockout of Y2 and/or Y4 receptors unmasks the ability of a single lipopolysaccharide injection to cause a delayed and prolonged increase in anxiety- and/or depression-like behaviour. These findings suggest that neuropeptide Y acting via Y2 and Y4 receptors prevents the development of long-term anxiety- and depression-like behaviour caused by acute immune challenge.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anxiety -
- Behavior, Animal -
- Depression -
- Exploratory Behavior -
- Female -
- Immunologic Factors - toxicity
- Lipopolysaccharides - toxicity
- Mice -
- Mice, 129 Strain -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Neuropeptide Y - physiology
- Receptors, Neuropeptide Y - genetics
- Signal Transduction -
- Stress, Physiological - immunology
- Swimming -
- Time Factors -
- Find related publications in this database (Keywords)
- anxiety-related behaviour
- bacterial lipopolysaccharide (endotoxin)
- depression-like behaviour
- neuropeptide-Y Y2 receptors
- neuropeptide-Y Y4 receptors