Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lange, U; Teichmann, J; Obermayer-Pietsch, B.
Genetic aspects of osteopenia/osteoporosis in ankylosing spondylitis.
Z Orthop Unfall. 2009; 147(5): 577-581.
Doi: 10.1055/s-0029-1185711
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
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- Abstract:
- Aim: Secondary osteoporosis with subsequent fractures are well-known symptoms in ankylosing spondylitis. As a possible genetic component of osteoporosis, an association between bone mineral density (BMD) and polymorphisms of the vitamin D receptor (VDR) gene has been reported. Method: In the present study, we investigated relationships between these polymorphisms, BMD, biochemical markers of bone metabolism and markers of disease activity in ankylosing spondylitis. Results: AS patients showed osteoporosis more frequently than healthy controls. A mapping of activity indices and BMD showed an association of lumbar and peripheral BMD as well as of the current and median C-reactive protein over the last 3 years with the used Fokl-genotypes of the VDR in male patients with AS. Female AS patients showed no significant association. Conclusion: The pathophysiological mechanisms of this association are unclear, especially with respect to the inflammatory activity. An early assessment of the risk for osteopenia/osteoporosis in AS patients using molecular biological tests could make possible timely preventive measures or therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorptiometry, Photon -
- Adult -
- Alleles -
- Bone Density - genetics
- Bone Diseases, Metabolic - genetics
- C-Reactive Protein - metabolism
- Chromosomes, Human, Pair 12 - genetics
- Female -
- Genotype -
- Heterozygote Detection -
- Homozygote -
- Humans -
- Male -
- Middle Aged -
- Osteoporosis - genetics
- Polymerase Chain Reaction -
- Polymorphism, Genetic - genetics
- Receptors, Calcitriol - genetics
- Sex Factors -
- Spondylitis, Ankylosing - diagnosis Spondylitis, Ankylosing - genetics Spondylitis, Ankylosing - immunology
- Find related publications in this database (Keywords)
- ankylosing spondylitis
- osteopenia/osteoporosis
- genetic aspects
- vitamin D receptor gene polymorphisms