Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stanzer, S; Janesch, B; Resel, M; Augustin, T; Samonigg, H; Bauernhofer, T.
The role of activation-induced cell death in the higher onset of spontaneous apoptosis of NK cell subsets in patients with metastatic epithelial cancer.
Cell Immunol. 2010; 261(2):99-104
Doi: 10.1016/j.cellimm.2009.11.006
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Stanzer Stefanie
- Co-Autor*innen der Med Uni Graz
- Bauernhofer Thomas
- Samonigg Hellmut
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- Abstract:
- To address the question whether the higher onset of apoptosis of circulating NK cell subsets might be activation induced in cancer patients, surface expression of NKG2D and serum (s) levels of MHC class I chain-related (MIC) proteins in relation to apoptosis marker and CD95 expression on NK cells were evaluated. Patients showed a significantly higher onset of spontaneous apoptosis of CD56dim NK cells. No difference in the CD95 expression could be detected between patients and normal controls (NCs). Patients' CD56bright NK cells demonstrated a higher expression of NKG2D compared to CD56dim NK cells. The sMICB levels showed a higher level in patients versus NCs. No correlation between sMIC protein levels with both NKG2D expression and onset of spontaneous apoptosis of NK cell subsets was found. Our data suggest that the higher onset of apoptosis of circulating NK cell subsets of patients is not triggered by activation-induced cell death.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antigens, CD95 - immunology
- Apoptosis - immunology
- Cell Death - immunology
- Female -
- Histocompatibility Antigens Class I - immunology
- Humans -
- Killer Cells, Natural - cytology Killer Cells, Natural - immunology
- Male -
- Middle Aged -
- NK Cell Lectin-Like Receptor Subfamily K - immunology
- Neoplasm Metastasis -
- Neoplasms, Glandular and Epithelial - immunology Neoplasms, Glandular and Epithelial - pathology
- Find related publications in this database (Keywords)
- MHC like proteins
- CD95
- NKG2D
- Tumour immunity