Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Golaszewski, SM; Bergmann, J; Christova, M; Nardone, R; Kronbichler, M; Rafolt, D; Gallasch, E; Staffen, W; Ladurner, G; Beisteiner, R.
Increased motor cortical excitability after whole-hand electrical stimulation: A TMS study.
Clin Neurophysiol. 2010; 121(2): 248-254.
Doi: 10.1016/j.clinph.2009.09.024
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Christova Monica
- Gallasch Eugen
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- Abstract:
- Objective: To examine the neuromodulatory effect of whole-hand mesh-glove (MG) stimulation on motor cortical pathways, we explored motor cortical excitability before and after suprathreshold whole-hand MG stimulation using transcranial magnetic stimulation (TMS). Methods: Twenty-eight healthy volunteers (14 controls) were studied at baseline, immediately post and 1 h post-MG stimulation for 30 min. Motor thresholds (MTs), motor evoked potentials (MEPs) recruitment curve, short intracortical inhibition (SICI) and intracortical facilitation (ICF) after paired magnetic stimuli were evaluated. Results: After MG stimulation the MTs were significantly reduced and slope of MEP recruitment curve significantly increased; furthermore, the stimulation led to a sustained decrease of SICI and increase of ICF in the contralateral motor cortex. These effects lasted for at least 60 min and were stronger 1 h post-stimulation compared with testing immediately after stimulation. A sham group did not show any differences before and after MG stimulation. Conclusions: We provide a first demonstration that MG whole-hand stimulation induces increases in motor cortical excitability lasting at least 1 h. Both the strength of the corticospinal projections and the inhibitory and facilitatory intracortical mechanisms are involved. Synaptic modifications such as long-term potentiation mechanisms may underlie this stimulation-induced cortical plasticity changes. Significance: Present results prove the MG stimulation to be a promising tool in neurorehabilitation. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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- Adult -
- Afferent Pathways - physiology
- Electric Stimulation - methods
- Evoked Potentials, Motor - physiology
- Female -
- Functional Laterality - physiology
- Hand - innervation
- Humans -
- Long-Term Potentiation - physiology
- Male -
- Middle Aged -
- Motor Cortex - physiology
- Neural Conduction - physiology
- Neural Inhibition - physiology
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- Pyramidal Tracts - physiology
- Reaction Time - physiology
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- Transcranial Magnetic Stimulation - methods
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- Find related publications in this database (Keywords)
- Transcranial magnetic stimulation
- Mesh-glove
- Motor cortex excitability
- Somatosensory stimulation
- Neuroplasticity