Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Tomaschitz, A; Pilz, S; Ritz, E; Obermayer-Pietsch, B; Pieber, TR.
Aldosterone and arterial hypertension.
Nat Rev Endocrinol. 2010; 6(2): 83-93.
Doi: 10.1038/nrendo.2009.263
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Tomaschitz Andreas
- Co-authors Med Uni Graz
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Pilz Stefan
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- Abstract:
- In the setting of primary aldosteronism, elevated aldosterone levels are associated with increased blood pressure. Aldosterone concentrations within the normal range, however, can also alter blood pressure. Furthermore, the aldosterone-to-renin ratio, an indicator of aldosterone excess, is associated with hypertension, even in patients without excessive absolute aldosterone levels. In this Review we assess the data on the role of aldosterone in the development and maintenance of hypertension. We provide an overview of the complex crosstalk between genetic and environmental factors, and about aldosterone-mediated arterial hypertension and target organ damage. The discussion is organized according to major targets of aldosterone action: the collecting duct in the kidney, the vasculature and the central nervous system. The antihypertensive efficacy of mineralocorticoid-receptor blockers, even in patients with aldosterone values in the normal range, supports the evidence that aldosterone plays a part in blood pressure elevation in the absence of primary aldosteronism.
- Find related publications in this database (using NLM MeSH Indexing)
- Aldosterone - genetics Aldosterone - pharmacology Aldosterone - physiology
- Aldosterone Synthase - genetics
- Animals -
- Antihypertensive Agents -
- Blood Pressure -
- Blood Vessels - drug effects
- Brain - drug effects
- Ethnic Groups -
- Genetic Predisposition to Disease -
- Homeostasis -
- Humans -
- Hyperaldosteronism -
- Hypertension - etiology Hypertension - genetics
- Kidney Tubules, Collecting - drug effects
- Receptors, Mineralocorticoid - antagonists and inhibitors
- Renin - blood
- Renin-Angiotensin System -