Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bernhard, H; Deutschmann, A; Leschnik, B; Novak, M; Hauer, A; Haidl, H; Rosenkranz, A; Muntean, W.
Calibrated automated thrombin generation in paediatric patients with inflammatory bowel disease
HAMOSTASEOLOGIE. 2009; 29: S90-S93.
Doi: 10.1055/s-0037-1621491
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Bernhard Heike
- Muntean Eugen
- Co-Autor*innen der Med Uni Graz
- Deutschmann Andrea
- Ehammer-Rosenkranz Andrea
- Haidl Harald
- Hauer Almuthe
- Leschnik Bettina
- Novak Michael Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In adults, inflammatory bowel disease (IBD) is associated with an increased risk of thromboembolic complications. The pathogenesis of IBD is not really clear and a high thrombin activity might contribute to disease progression. We wanted to see whether children with IBD have a higher thrombin generation (TG). PATIENTS, MATERIAL, METHODS: Plasma samples were collected of 20 patients with IBD and of 60 healthy controls (age range from 10 to 19). TG was measured by means of Calibrated automated thrombography (CAT). The disease activity was estimated, using the Pediatric Crohn's Disease Activity Index (PCDAI) for Crohn's disease and the Pediatric Ulcerative Colitis Disease Activity Index (PUCAI) for Ulcerative Colitis. In addition, we investigated F1+F2, TAT, TFPI and fibrinogen. RESULTS: There was a significant increase of endogenous thrombin potential (ETP), lag time and time to peak in patients with IBD, while peak showed no difference to healthy controls. ETP and F1+F2 in children with IBD also showed a significant correlation with PCDAI (PUCAI) and fibrinogen. CONCLUSION: IBD in children is associated with high TG, but this seems to be caused mainly by the inflammatory process and not by any individual disposition.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Blood Chemical Analysis - methods
- Case-Control Studies -
- Child -
- Fibrinogen - metabolism
- Humans -
- Inflammatory Bowel Diseases - blood Inflammatory Bowel Diseases - pathology
- Peptide Fragments - blood
- Protein Precursors - blood
- Prothrombin -
- Thrombin - metabolism
- Young Adult -
- Find related publications in this database (Keywords)
- Calibrated automated thrombography
- endogenous thrombin potential
- inflammatory bowel disease