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Castellani, C; Zanoni, G; Tangl, S; van Griensven, M; Redl, H.
Biphasic calcium phosphate ceramics in small bone defects: potential influence of carrier substances and bone marrow on bone regeneration
CLIN ORAL IMPLANT RES. 2009; 20(12): 1367-1374. Doi: 10.1111/j.1600-0501.2009.01760.x
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Leading authors Med Uni Graz: Castellani Christoph
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Abstract:: Objectives Synthetic calcium phosphate bone substitutes such as hydroxyapatite (HA), beta-tricalcium phosphate (beta-TCP) or mixtures are alternatives to autogenous bone grafts. TricOs T (R) and Collagraft (R) are resorbable bone substitutes consisting of biphasic calcium phosphate and a bioactive matrix. Both products have a similar HA to beta-TCP ratio, but differ by their matrix. It was the aim of this study to determine the influence of matrix and autologous bone marrow on bone regeneration in a rabbit femoral condyle model. Material and methods A critical-sized bicortical channel with a diameter of 4.5 mm was drilled through the femoral condyles in male New Zealand rabbits. Collagraft (R) with bone marrow harvested from the posterior iliac crest or TricOs T (R) with and without bone marrow was introduced into the defect. Rabbits were euthanized 8 weeks later. The percentage of newly formed bone was determined by micro-computed tomography. Results There was no significant difference between bone ingrowth at 8 weeks. Thus, TricOs T (R) without bone marrow showed similar bone ingrowth as Collagraft (R) with bone marrow. Furthermore, no increase of bone ingrowth could be achieved by adding bone marrow to TricOs T (R) in the present setting. Conclusion Both bone substitutes showed similar bone ingrowth in this investigation. Using TricOs T (R) without bone marrow could avoid donor site morbidity due to harvesting of bone marrow. Further prospective clinical trials will be needed to investigate this approach. To cite this article:Castellani C, Zanoni G, Tangl S, van Griensven M, Redl H. Biphasic calcium phosphate ceramics in small bone defects: potential influence of carrier substances and bone marrow on bone regeneration.Clin. Oral Impl. Res. 20, 2009; 1367-1374.doi: 10.1111/j.1600-0501.2009.01760.x.
Find related publications in this database (Keywords): bone grafts; bone marrow; Collagraft (R); micro-computed tomography; TricOs T (R)