Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rueff, F; Przybilla, B; Bilo, MB; Muller, U; Scheipl, F; Aberer, W; Birnbaum, J; Bodzenta-Lukaszyk, A; Bonifazi, F; Bucher, C; Campi, P; Darsow, U; Egger, C; Haeberli, G; Hawranek, T; Korner, M; Kucharewicz, I; Kuchenhoff, H; Lang, R; Quercia, O; Reider, N; Severino, M; Sticherling, M; Sturm, GJ; Wuthrich, B.
Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity.
J ALLERG CLIN IMMUNOL. 2009; 124(5): 1047-1054.
Doi: 10.1016/j.jaci.2009.08.027
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
- Sturm Gunter
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- Abstract:
- Background: Severe anaphylaxis to honeybee or vespid stings is associated with a variety of risk factors, which are poorly defined. Objective: Our aim was to evaluate the association of baseline serum tryptase concentrations and other variables routinely recorded during patient evaluation with the frequency of past severe anaphylaxis after a field sting. Methods: In this observational multicenter study, we enrolled 962 patients with established bee or vespid venom allergy who had a systemic reaction after a field sting. Data were collected on tryptase concentration, age, sex, culprit insect, cardiovascular medication, and the number of preceding minor systemic reactions before the index field sting. A severe reaction was defined as anaphylactic shock, loss of consciousness, or cardiopulmonary arrest. The index sting was defined as the hitherto first, most severe systemic field-sting reaction. Relative rates were calculated with generalized additive models. Results: Two hundred six (21.4%) patients had a severe anaphylactic reaction after a field sting. The frequency of this event increased significantly with higher tryptase concentrations (nonlinear association). Other factors significantly associated with severe reactions after a field sting were vespid venom allergy, older age, male sex, angiotensin-converting enzyme inhibitor medication, and 1 or more preceding field stings with a less severe systemic reaction. Conclusion: In patients with honeybee or vespid venom allergy, baseline serum tryptase concentrations are associated with the risk for severe anaphylactic reactions. Preventive measures should include substitution of angiotensin-converting enzyme inhibitors. (J Allergy Clin Immunol 2009;124:1047-54.)
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anaphylaxis - blood
- Animals -
- Bee Venoms - immunology
- Cohort Studies -
- Female -
- Humans -
- Hypersensitivity - immunology
- Insect Bites and Stings - immunology
- Male -
- Middle Aged -
- Prognosis -
- Prospective Studies -
- Retrospective Studies -
- Tryptases - blood
- Wasps - immunology
- Find related publications in this database (Keywords)
- Hymenoptera venom
- allergy
- anaphylactic shock
- tryptase
- risk factors
- angiotensin-converting enzyme inhibitor
- age
- sex