Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Machold, KP; Kiener, HP; Graninger, W; Graninger, WB.
Soluble intercellular adhesion molecule-1 (sICAM-1) in patients with rheumatoid arthritis and systemic lupus erythematosus.
Clin Immunol Immunopathol. 1993; 68(1): 74-78.
Doi: 10.1006/clin.1993.1098
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- Co-Autor*innen der Med Uni Graz
- Graninger Winfried
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- Abstract:
- Serum levels of the soluble form of the intercellular adhesion molecule-1 (sICAM-1) have been advocated as a parameter of clinical relevance in determining the activation of the immune system in inflammatory disease(s). We have determined sICAM-1 levels in 46 patients with rheumatoid arthritis (RA), in 53 patients with systemic lupus erythematosus (SLE), and in 82 healthy controls using a commercially available ELISA system. When compared to the healthy controls, sICAM-1 levels of the patients did not differ statistically significantly nor was there any difference between the patient groups. However, there was a strong correlation within the patient groups between sICAM-1 levels and conventional measures of disease activity. Thus, although sICAM-1 may be of theoretical interest with regard to immune activation, our results do not support the view of sICAM-1 providing additional information to the clinical rheumatologist when it is compared to more conventional measures such as acute-phase proteins or clinical activity scores.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Arthritis, Rheumatoid - blood
- Cell Adhesion Molecules - blood
- Diagnosis-Related Groups -
- Female -
- Humans -
- Intercellular Adhesion Molecule-1 -
- Longitudinal Studies -
- Lupus Erythematosus, Systemic - blood
- Male -
- Middle Aged -
- Reference Values -
- Severity of Illness Index -
- Solubility -