Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Graninger, W; Wenisch, C; Wiesinger, E; Menschik, M; Karimi, J; Presterl, E.
Experience with outpatient intravenous teicoplanin therapy for chronic osteomyelitis.
Eur J Clin Microbiol Infect Dis. 1995; 14(7):643-647
Doi: 10.1007/BF01690746
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- Co-Autor*innen der Med Uni Graz
- Graninger Monika
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- Abstract:
- Thirty-seven patients with acute exacerbations of chronic osteomyelitis caused by methicillin-susceptible Staphylococcus aureus (n = 13), methicillin-resistant Staphylococcus aureus (n = 12), methicillin-susceptible coagulase-negative staphylococci (n = 9), methicillin-resistant coagulase-negative staphylococci (n = 1) and enterococci (n = 2) were treated intravenously with teicoplanin. After a loading dose of 7 to 16 mg/kg (median 11 mg/kg) for 4 to 7 days, patients received 9 to 25 mg/kg (median 14 mg/kg) on Mondays, Wednesdays and Fridays in an outpatient setting to reach trough serum levels between 5 mg/l and 15 mg/l. The duration of treatment ranged from 28 to 150 days (median 60 days). Cure was obtained in 14 (38%) and improvement in 17 (46%) cases, and failure was observed in 6 (16%) patients. Adverse effects occurred in 6 patients, and caused discontinuation of treatment in 3 patients. The financial savings exceeded US$60,000 per patient compared with the high hospitalization costs of inpatient treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Ambulatory Care Facilities -
- Anti-Bacterial Agents - therapeutic use
- Child -
- Chronic Disease -
- Female -
- Humans -
- Injections, Intravenous -
- Male -
- Middle Aged -
- Osteomyelitis - drug therapy
- Staphylococcal Infections - drug therapy
- Teicoplanin - administration and dosage Teicoplanin - therapeutic use