Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kotzailias, N; Graninger, M; Knechtelsdorfer, M; Jilma, B.
Acute effects of hyperglycaemia on plasma concentration of soluble P-selectin and von Willebrand factor in healthy volunteers -a prospective randomised double blind controlled study.
Thromb Res. 2009; 123(3):452-459
Doi: 10.1016/j.thromres.2008.06.015
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Graninger Monika
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- Abstract:
- This study set out to clarify if isolated hyperglycaemia may directly induce acute endothelial and/or platelet activation as diabetes mellitus is a major risk factor for cardio- and cerebrovascular diseases with thromboembolic complications. 12 healthy volunteers were investigated in a prospective randomised, double blind, three-way cross-over trial with a wash-out period of 21 days. Normoglycemic (4.72 mmol/L), moderate (11.1 mmol/L) or high grade (16.7 mmol/L) glucose clamps were maintained for 6 hours by infusion of glucose, insulin and somatostatin. Volunteers were observed for 24 hours. An increase in soluble (s)P-selectin and von Willebrand Factor (VWF) concentrations, of 26+/-15% and 21+/-7%, respectively was observed 24 hours after euglycaemic treatment, of 20+/-7% and 19+/-5%, respectively after moderate hyperglycaemia and of 22+/-13% and 18+/-7%, respectively after high grade hyperglycaemia at 24 hours (p<0.6 and p<0.004 in all periods and p=0.2-0.9 between periods). In conclusion, acute hyperglycaemia for 6 hours does not increase the platelet and endothelial activation markers sP-selectin and VWF in healthy volunteers.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biomarkers - blood
- Blood Platelets - metabolism
- Cardiovascular Diseases - blood
- Cardiovascular Diseases - etiology
- Cerebrovascular Disorders - blood
- Cerebrovascular Disorders - etiology
- Diabetes Complications - blood
- Diabetes Complications - etiology
- Double-Blind Method -
- Glucose Clamp Technique -
- Hemoglobins - metabolism
- Humans -
- Hyperglycemia - blood
- Male -
- P-Selectin - blood
- Platelet Count -
- Prospective Studies -
- Risk Factors -
- Solubility -
- von Willebrand Factor - metabolism
- Find related publications in this database (Keywords)
- Diabetes
- Glucose clamp
- von Willebrand Factor
- sP-selectin
- Platelet and endothelial activation