Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Marsik, C; Graninger, M; Mackman, N; Osterud, B; Luther, T; Jilma, B.
Effects of enalapril on disseminated intravascular thrombin formation during systemic inflammation.
Cardiovasc Res. 2003; 60(1):131-135
Doi: 10.1016/S0008-6363(03)00363-8
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- Co-Autor*innen der Med Uni Graz
- Graninger Monika
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- Abstract:
- Tissue factor (TF), the main trigger of coagulation is important in the propagation of cardiovascular diseases. Based on an in vitro study, we hypothesised that enalapril may blunt the endotoxin-induced, TF-triggered coagulation in humans. In a randomised, controlled trial, 30 healthy male volunteers received 2 ng/kg of lipopolysaccharide (LPS) after pre-treatment with placebo or enalapril for 5 days or with enalapril 2 h before LPS infusion. Infusion of LPS increased interleukin-6 levels 400 fold, and induced a 10-fold increase in prothrombin fragment, a fourfold increase in D-dimer, and a fivefold increase in plasmin-antiplasmin complexes. However, pre-treatment with enalapril did not blunt LPS-induced coagulation. Our trial provides evidence against a modulatory role of angiotensin converting enzyme in LPS-induced, TF-triggered coagulation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Analysis of Variance -
- Angiotensin-Converting Enzyme Inhibitors - therapeutic use
- Disseminated Intravascular Coagulation - immunology
- Disseminated Intravascular Coagulation - microbiology
- Disseminated Intravascular Coagulation - prevention & control
- Enalapril - therapeutic use
- Fibrin Fibrinogen Degradation Products - analysis
- Fibrinolysin - analysis
- Humans -
- Infusions, Intravenous -
- Interleukin-6 - blood
- Leukocytes, Mononuclear - chemistry
- Lipopolysaccharides - administration & dosage
- Male -
- Prothrombin - analysis
- Statistics, Nonparametric -
- Thromboplastin - analysis
- Find related publications in this database (Keywords)
- angiotensin converting enzyme
- endotoxins
- enalapril
- prothrombin fragment
- D-dimer
- randomised controlled trial